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Ceralasertib

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SI-7573

Ceralasertib, >98% (HPLC)

CAS No. : [1352226-88-0]

Synonyms : AZD-6738

IUPAC Name : (R)-Imino(methyl)(1-(6-((R)-3-methylmorpholino)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)cyclopropyl)-l6-sulfanone

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Chemical Properites
Mol. Formula :
C20H24N6O2S
Mol. Weight :
412.51
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ceralasertib selectively inhibits ATR with nanomolar potency (IC50 = 1 nM) and shows good oral exposure. It is a valuable tool compound for probing ATR‑dependent DNA repair pathways and evaluating therapeutic strategies targeting replication stress in cancer.

References : Vendetti F.P. et al.: Oncotarget, 6(42), 44289-305, 2015; Kwok M. et al.: Blood, 127(5), 582-95, 2016; Min A. et al.: Mol. Cancer Ther., 16(4),566-577, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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