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Cerdulatinib hydrochloride

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SI-6283

Cerdulatinib hydrochloride, >98% (HPLC)

CAS No. : [1369761-01-2]

Synonyms : PRT-062070 hydrochloride; PRT-2070 hydrochloride

IUPAC Name : 4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride

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Chemical Properites
Mol. Formula :
C20H27N7O3S • HCl
Mol. Weight :
482
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Cerdulatinib hydrochloride selectively inhibits SYK and JAK kinases with low‑nanomolar potency (IC50 = 32 nM for SYK; 0.5/12/6/8 nM for TYK2/JAK1/JAK2/JAK3). As an orally active, reversible ATP‑competitive inhibitor, it is valuable for dissecting signaling pathways involved in autoimmune disease and B‑cell–driven cancers.

References : Coffey G. et al., J. Pharmacol. Exp. Ther., 351(3), 538-48, 2014. Ishikawa C. et al.: Int. J. Oncol., 53(4), 1681-1690, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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