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Cevipabulin fumarate

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SI-6263

Cevipabulin fumarate, >98% (HPLC)

CAS No. : [849550-67-0]

Synonyms : TTI-237 fumarate

IUPAC Name : (S)-5-Chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine fumarate

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Chemical Properites
Mol. Formula :
C18H18ClF5N6O • C4H4O4
Mol. Weight :
580.9
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Cevipabulin fumarate is a microtubule‑active small molecule that inhibits [3H]NSC-49842–tubulin binding and shows strong cytotoxicity (IC50 = 18–40 nM) across human cancer cell lines. It is a useful tool for probing microtubule‑dependent antitumor pathways.

References : Beyer C. F. et al.: Cancer Res., 68(7), 2292-300, 2008; Beyer C. F. et al.: Cancer Chemother. Pharmacol., 64(4), 681-9, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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