CFI-401870

SI-4115

CFI-401870, >98% (HPLC)

CAS No. : [1430741-35-7]

IUPAC Name : N-((R)-Cyclopropyl(pyridin-2-yl)methyl)-3-(4-((endo)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 01 November 2026
10MG	Request A Quote		Back Order	Estimated to ship on 01 November 2026
25MG	Request A Quote		Back Order	Estimated to ship on 01 November 2026
50MG	Request A Quote		Back Order	Estimated to ship on 01 November 2026
100MG	Request A Quote		Back Order	Estimated to ship on 01 November 2026

Applications : CFI-401870 is a orally bioavailable, potent tyrosine threonine kinase (TTK) inhibitor (TTK IC₅₀ < 10 nM, HCT116 GI₅₀ < 0.1 μM). CFI-401870 displayed low off-target activity (>500×), and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing, and was selected for preclinical evaluation.

References : Liu Y. et al.: J. Med. Chem., 58(8), 3366-3392, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.