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CHIR-090

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SI-5620

CHIR-090, >98% (HPLC)

CAS No. : [728865-23-4]

MDL No. : MFCD22665727

IUPAC Name : N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide

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Chemical Properites
Mol. Formula :
C24H27N3O5
Mol. Weight :
437.50
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM.

References : Barb A. W. et al.: Biochemistry 46(12), 3793-802, 2007; Barb A. W. et al.: Proc Natl Acad Sci U S A. 104(47),18433-8, 2007; Tan J. H. et al.: Antimicrob Agents Chemother., 61(7), e02223-16, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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