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Chloroquine dihydrochloride

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SI-5539

Chloroquine dihydrochloride, >98% (HPLC)

CAS No. : [3545-67-3]

IUPAC Name : N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride

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25MGRequest A Quote
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Chemical Properites
Mol. Formula :
C18H26ClN3 . 2HCl
Mol. Weight :
392.79
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).

References : Said A. et al.: J. Immunol., 193(12), 6135-43, 2014; Tuomela J. et al.: Oncol Lett., 6(6), 1665-1672, 2013; Mohamed F. E. et al.: Liver Int., 35(3):1063-76, 2015; Colson P. et al.: Int J. Antimicrob Agents55(4), 105932, 2020; Savarino A. et al.: J. Clin Virol., 20(3), 131-135, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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