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CHU-128

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SI-8070

CHU-128, >98% (HPLC)

CAS No. : [2212020-93-2]

IUPAC Name : 3-((1S,2S)-1-(5-(2,2-Dimethylmorpholino)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C47H47F2N11O5
Mol. Weight :
883.96
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : CHU‑128 is a GLP‑1 receptor agonist with pronounced signaling bias: it selectively engages the Gs/cAMP pathway without activating Gq/calcium responses, ERK signaling, or β‑arrestin pathways. It is applied in research on type 2 diabetes and GLP‑1R‑mediated metabolic regulation.

References : Malik F. et al., Br. J. Pharmacol., 179(4), 511-525, 2022; Zhang X. et al., Mol. Cell, 80(3), 485-500, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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