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Cilofexor

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SI-6089

Cilofexor, >98% (HPLC)

CAS No. : [1418274-28-8]

Synonyms : GS-9674

IUPAC Name : 2-(3-(2-Chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid

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Chemical Properites
Mol. Formula :
C28H22Cl3N3O5
Mol. Weight :
586.85
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Cilofexor activates FXR with an EC50 of 43 nM and functions as a selective, orally active nonsteroidal agonist. Its anti‑inflammatory and antifibrotic properties support its application in PSC and NASH research.

References : Trauner M. et al.: Hepatology, 70(3), 788-801, 2019; Patel K. et al.: Hepatology, 2020; Schwab P. et al.: 68(1), S471-S472, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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