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Clobetasol dipropionate 9-fluoro impurity

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Clobetasol dipropionate 9-fluoro impurity, >98%

CAS No. : [2412496-00-3]

Synonyms : Clobetasol acetic acid impurity; Clobetasol impurity RRT 0.46; Clobetasol propionate EP impurity F

IUPAC Name : (E)-2-((8S,9R,10S,11S,13S,14S,16S)-9-Fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-3,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)acetic acid

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Chemical Properites
Mol. Formula :
C22H27FO4
Mol. Weight :
374.45
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Clobetasol 17-propionate, which is a potent, selective CYP3A5 inhibitor (IC50: 0.206 μM) that does not inhibit CYP3A4 or other major CYPs. As a corticosteroid, it is used in research on psoriasis and other skin conditions.

References : Brandi N. et al.: J. Dermatolog. Treat. 30(8), 757-759, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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