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Clobetasol propionate EP impurity J

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Clobetasol propionate EP impurity J, >98%

CAS No. : [1486466-31-2]

Synonyms : Clobetasol propionate 17α-spiro compound; Clobetasol propionate USP related compound A

IUPAC Name : (8S,9R,10S,11S,13S,14S,16S,17R)-4'-Chloro-5'-ethyl-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,3'(6H)-dione

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Chemical Properites
Mol. Formula :
C25H30ClFO4
Mol. Weight :
448.96
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Clobetasol 17-propionate, which is a potent, selective CYP3A5 inhibitor (IC50: 0.206 μM) that does not inhibit CYP3A4 or other major CYPs. As a corticosteroid, it is used in research on psoriasis and other skin conditions.

References : Brandi N. et al.: J. Dermatolog. Treat. 30(8), 757-759, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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