Clozapine

SL-8090

Clozapine, >98%

CAS No. : [5786-21-0]

Synonyms : HF 1854

IUPAC Name : 8-Chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
1G	Request A Quote		Back Order	Estimated to ship on 04 October 2026
5G	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Clozapine is an antipsychotic medication used in schizophrenia research, notable for its high affinity for various neuroreceptors. It acts as a potent dopamine D2 antagonist with a Ki of 75 nM, inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM respectively, and serves as a potent and selective agonist at the muscarinic M4 receptor with an EC50 of 11 nM.

References : Seeman P. et al.: ACS Chem Neurosci., 5(1), 24-29, 2014; Zhukovskaya N. L. et al.: Neurosci Lett., 288(3), 236-240, 2000; Moreno J. L. et al.: Psychopharmacology (Berl), 225(1), 217-226, 2013; Zorn S. H. et al.: Eur. J. Pharmacol., 269(3), R1-2, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.