CMKLR1 antagonist 1

SI-7404

CMKLR1 antagonist 1, >98% (HPLC)

CAS No. : [3033101-08-2]

IUPAC Name : (S)-3-(4-((1-Cyclopentyl-3-(3,5-dichloro-4-(hydroxymethyl)phenyl)-4-fluoro-1H-indazol-6-yl)methoxy)phenyl)butanoic acid

Price And Availability
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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : This phenylindazole‑derived CMKLR1 antagonist was identified through GPCR‑focused screening and structure‑based optimization. It shows potent CMKLR1 inhibition (pIC₅₀ = 7.44), along with oral bioavailability and favorable PK in mice. In the imiquimod‑induced psoriasis‑like model, 1‑week oral dosing significantly reduced erythema, scaliness, and skin thickness, highlighting strong therapeutic potential for psoriasis and immune‑driven inflammatory diseases.

References : Ko B. et al.: J. Med. Chem., 66(21), 14564-14582, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.