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CMP-5 dihydrochloride

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SI-7076

CMP-5 dihydrochloride, >98% (HPLC)

CAS No. : [2309409-79-6]

IUPAC Name : 1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine dihydrochloride

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Chemical Properites
Mol. Formula :
C21H21N3 • 2HCl
Mol. Weight :
388.34
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : CMP‑5 dihydrochloride selectively targets PRMT5, inhibiting S2Me‑H4R3 formation on histone substrates and displaying no measurable activity against PRMT1, PRMT4, or PRMT7. Functionally, it blocks EBV‑driven B‑cell transformation while leaving normal B cells unaffected.

References : Alinari L. et al.: Blood, 125(16), 2530-43, 2015; Webb L. M. et al., J. Immunol., 198(4), 1439-1451, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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