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Cobimetinib hemifumarate

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SI-5525

Cobimetinib hemifumarate, >98% (HPLC)

CAS No. : [1369665-02-0]

Synonyms : GDC-0973 hemifumarate; RG7420 hemifumarate

IUPAC Name : (S)-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone hemifumarate

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Chemical Properites
Mol. Formula :
C21H21F3IN3O2 . 05 C4H4O4
Mol. Weight :
589.34
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, for the potential treatment of cancer.

References : Hoeflich K. P. et al.: Cancer Res., 72(1), 210-9, 2012; Choo E. F. et al.: Cancer Chemother Pharmacol., 71(1), 133-43, 2013; Wong H. et al.: Clin Cancer Res., 18(11), 3090-9, 2012; Corazao-Rozas P. et al.: Oncotarget., 7(26), 39473-39485, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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