Cortisone

SL-10379

Cortisone, >98%

CAS No. : [[53-06-5]]

Synonyms : 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E

IUPAC Name : (8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-3,11(2H)-dione

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Applications : Cortisone is an oxidized metabolite of Cortisol and functions as both an immunosuppressant and anti-inflammatory agent. At elevated concentrations, Cortisone may partially interfere with the binding of glucocorticoids to their respective glucocorticoid receptors.

References : Hirano T. et al.: Int. Immunopharmacol., 1(12), 2109-15, 2001; McCue R. E. et al.: Inflammation, 3(2), 159-76, 1978; Seleem D. et, al.: Biol Pharm Bull., 41(8), 1299-1302, 2018; Rusu V. M. et al.: J. Immunol., 115(5), 1370-4, 1975.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.