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Corubrutinib

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SI-6904

Corubrutinib, >98% (HPLC)

CAS No. : [2247614-80-6]

Synonyms : BIIB-091

IUPAC Name : (R)-1-(tert-Butyl)-N-(8-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)-1H-1,2,3-triazole-4-carboxamide

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Chemical Properites
Mol. Formula :
C28H34N10O2
Mol. Weight :
542.65
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Corubrutinib is a potent, selective, orally active, reversible BTK inhibitor (IC50 < 0.5 nM) that binds BTK and stabilizes Tyr551 in an inactive conformation with high affinity. It is used in the research of multiple sclerosis and other BTK‑mediated immune disorders.

References : Hopkins T. B. et al.: J. Med. Chem., 65(2), 1206-1224, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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