CPI-455

SI-6687

CPI-455, >98% (HPLC)

CAS No. : [1628208-23-0]

IUPAC Name : 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : CPI‑455 is a potent pan‑KDM5 inhibitor (IC₅₀ = 10 nM for KDM5A) that drives global accumulation of H3K4me3 and suppresses the emergence of drug‑tolerant persister cells in cancer models treated with cytotoxic or targeted agents.

References : Vinogradova M. et al.: Nat. Chem. Biol., 12(7), 531-8, 2016; Xiang Yuan, et al.: Cancer Immunol. Res., 7(9), 1440-1456, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.