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Crozbaciclib fumarate

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SI-7796

Crozbaciclib fumarate, >98% (HPLC)

CAS No. : [2567494-39-5]

IUPAC Name : 5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indol]-5'-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidin-2-amine fumarate

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Chemical Properites
Mol. Formula :
C28H30F2N6 • C4H4O4
Mol. Weight :
604.66
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Crozbaciclib fumarate selectively inhibits CDK4 and CDK6 with low‑nanomolar potency (IC50 = 3 nM and 1 nM), making it a valuable tool compound for probing CDK4/6‑mediated cell‑cycle progression and proliferation control.

References : Yin L. et al.: Eur. J. Med. Chem., 144, 1-28, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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