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Cyclobutenylindole efavirenz

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SL-6657

Cyclobutenylindole efavirenz, >98%

CAS No. : [2177283-35-9]

IUPAC Name : Ethyl 5-chloro-2-(cyclobut-1-en-1-yl)-3-(trifluoromethyl)-1H-indole-1-carboxylate

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Chemical Properites
Mol. Formula :
C16H13ClF3NO2
Mol. Weight :
343.73
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an analog of Efavirenz, which is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor, an antiretroviral drug used to treat and prevent HIV/AIDS. Also which is used in the preparation of novel GSK-3β inhibitors as anticancer agents.

References : Braz V. A. et al.: Biochemistry, 49(3), 601-10, 2010; Funes H. A. et al.: J. Antimicrob Chemother., 70(8), 2249-54, 2015; Apostolova N. et al.: J. Hepatol., 59(4), 780-9, 2013; Caulk A. W. et al.: J. Biomech., 48(10), 2176-80, 2015; Choi M.J. et al.: Bull. Korean. Chem. Soc., 32, 2015, 2011; Otani M. et al.: Bioorg. Med. Chem. Lett.. 20, 4259, 2010; Jhan Y.H. et al.: Tetrahedron. Lett., 54, 1155, 2013; Hsieh J.C. et al.: Org. Biomolec. Chem., 10, 6404, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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