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CZS-241 hydrochloride

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SI-8031

CZS-241 hydrochloride, >98% (HPLC)

IUPAC Name : 2-Chloro-N-(2,5-difluorophenyl)-5-(((1-isopropyl-4-((5-methyl-1H-pyrazol-3-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)methyl)benzamide hydrochloride

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Chemical Properites
Mol. Formula :
C26H24ClF2N9O • HCl
Mol. Weight :
588.44
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : CZS‑241 hydrochloride selectively targets PLK4 with nanomolar potency and shows weak TRKA inhibition. It promotes apoptosis, triggers S/G2‑phase arrest, and exhibits strong antiproliferative effects in leukemia models while maintaining low toxicity toward normal cells.

References : Sun Y. et al.: J. Med. Chem., 66(4), 2396-2421, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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