D-1228V

SI-8114

D-1228V, >98% (HPLC)

CAS No. : [3034863-56-1]

Synonyms : c-Met-IN-18

IUPAC Name : (R)-5-(3-Ethynyl-5-fluoro-1H-indazol-7-yl)-1-(1-phenylethyl)pyrimidine-2,4(1H,3H)-dione

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : D-1228V is a type‑III, ATP‑competitive inhibitor of c‑MET with strong activity against wild‑type and D1228V mutant forms (IC₅₀= 0.013/0.20 µM). It is valuable for investigating c‑MET‑driven cancers. Its terminal alkyne group enables CuAAC click chemistry, facilitating linkage to azide‑bearing molecules for chemical biology applications.

References : Michaelides I. N. et al.: J. Med. Chem., 66(13), 8782-8807, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.