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D,L-Sulforaphane-d8 glutathione (butyl-d8)

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SL-1499

D,L-Sulforaphane-d8 glutathione (butyl-d8), >98% (CP)

Isotopic Purity : 98 atom % D

Related CAS No. : [289711-21-3] of the unlabelled compound

Synonyms : L-γ-Glutamyl-S-[[[4-(methylsulfinyl)butyl-d8]amino] -thioxomethyl]-L-cysteinylglycine; SFN-GSH-d8

IUPAC Name : L-Glutamyl-S-[[[4-(methylsulfinyl)butyl-d8]amino]thioxomethyl]-L-cysteinyl-glycine

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Chemical Properites
Mol. Formula :
C16H20D8N4O7S3
Mol. Weight :
492.66
Appearance :
White solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : It is a deuterium labelled conjugate of Sulforaphane (butyl-d8) and Glutathione. In vivo, sulforaphane conjugates with glutathione during metabolism. In animal models of prostate cancer, this conjugate displays antioxidative and anticancer chemotherapeutic activities, increasing levels of heme oxygenase 1 (HO-1), Nrf2, activated caspase 3, cleaved PARP, and Bax, decreasing levels of Keap1, Bcl-xl, 4E-BP1, mTOR, and cyclin D1, and slowing tumor growth.

References : Keum Y. S. et al.: Pharm Res. Oct, 26(10), 2324-2331, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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