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Dalpiciclib

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SI-7791

Dalpiciclib, >98% (HPLC)

CAS No. : [1637781-04-4]

Synonyms : SHR-6390

IUPAC Name : 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperidin-4-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

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25MGRequest A Quote
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Chemical Properites
Mol. Formula :
C25H30N6O2
Mol. Weight :
446.56
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Dalpiciclib selectively targets CDK4 and CDK6 with low‑nanomolar potency (IC50 = 12.4 nM and 9.9 nM), leading to effective suppression of tumor‑cell proliferation. It shows strong antitumor efficacy in breast cancer and esophageal squamous cell carcinoma.

References : Long F. et al.: Cancer Sci., 110(4), 1420-1430, 2019; Wang J. et al.: J. Transl. Med., 15(1), 127, 2017. Chen Z. et al.: Clin. Transl. Med., 10(4), e148, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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