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Dalpiciclib hydrochloride

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SI-7792

Dalpiciclib hydrochloride, >98% (HPLC)

CAS No. : [2891598-76-6]

Synonyms : SHR-6390 hydrochloride

IUPAC Name : 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperidin-4-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride

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Chemical Properites
Mol. Formula :
C25H30N6O2 • HCl
Mol. Weight :
483.01
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Dalpiciclib hydrochloride selectively targets CDK4 and CDK6 with low‑nanomolar potency (IC50 = 12.4 nM and 9.9 nM), resulting in effective suppression of tumor‑cell proliferation. It demonstrates strong antitumor activity in breast cancer and esophageal squamous cell carcinoma.

References : Perez-Garcia M. J. et al.: Nat. Med., 27(11), 1868-1869, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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