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Danoprevir

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SI-5229

Danoprevir, >98% (HPLC)

CAS No. : [850876-88-9]

MDL No. : MFCD16038038

Synonyms : RO5190591; RG7227; R7227; ITMN-191

IUPAC Name : (2R,6S,13aS,14aR,16aS,Z)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate

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Chemical Properites
Mol. Formula :
C35H46FN5O9S
Mol. Weight :
731.84
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Danoprevir is a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease. First clinical study using HCV protease inhibitor Danoprevir to treat COVID-19 patients.

References : Seiwert S. D. et al.: Antimicrob Agents Chemother., 52(12), 4432-4441, 2008; Bartels D. J. et al.: J Infect Dis., 198(6), 800-807, 2008; Imhof I. et al.: Hepatology 53(4), 1090-1099, 2011; Jiang Y. et al.: J. Med. Chem., 57(5) 1753-1769, 2014; Hongyi C. et al.: Medicine (Baltimore) 99(48), e23357, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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