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Daridorexant hydrochloride

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SI-5707

Daridorexant hydrochloride, >98% (HPLC)

CAS No. : [1792993-84-0]

Synonyms : Nemorexant hydrochloride; ACT-541468 hydrochloride

IUPAC Name : (S)-(2-(6-Chloro-7-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone hydrochloride

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Chemical Properites
Mol. Formula :
C23H23ClN6O2 . HCl
Mol. Weight :
487.39
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Daridorexant hydrochloride is a potent orexin receptor antagonist and has IC50s of 2 nM and 3 nM for OX1 receptor and OX2 receptor, respectively. This is used for the treatment of insomnia.

References : Dauvilliers Y. et al.: Ann Neurol ., 87(3), 347-356, 2020; 1: Ufer M. et al.: Sleep 45(3), zsab224, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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