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Darolutamide pyrazole butyl impurity

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Darolutamide pyrazole butyl impurity, >98%

CAS No. : [2415967-06-3]

IUPAC Name : tert-Butyl (S)-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)carbamate

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Chemical Properites
Mol. Formula :
C18H21ClN4O2
Mol. Weight :
360.84
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Darolutamide, which is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. It is used in the treatment of non-metastatic castration-resistant prostate cancer in men.

References : Moilanen A. M. et al.: Sci Rep., 5, 12007, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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