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Darovasertib

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SI-7533

Darovasertib, >98% (HPLC)

CAS No. : [1874276-76-2]

Synonyms : NVP-LXS-196; IDE-196; LXS-196

IUPAC Name : 3-Amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

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Chemical Properites
Mol. Formula :
C22H23F3N8O
Mol. Weight :
472.48
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Darovasertib selectively inhibits PKCα and PKCθ with low‑nanomolar potency and shows limited activity against GSK3β. Its pharmacological profile makes it a valuable tool compound for investigating PKC‑driven signaling in uveal melanoma.

References : Kapiteijn K. et al.: Cancer Res., 79(13), 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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