DB-008

SI-8137

DB-008, >98% (HPLC)

CAS No. : [2991637-98-8]

IUPAC Name : 4-(3-(4-Acryloylpiperazine-1-carbonyl)-4-fluorobenzyl)-6-ethynylphthalazin-1(2H)-one

Price And Availability
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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : DB-008 selectively inhibits PARP16 with sub‑micromolar potency (IC₅₀= 0.27 µM) and contains an acrylamide electrophile that facilitates covalent labeling. It is cell‑permeable and selectively enriches PARP16. The presence of an alkyne group makes DB008 compatible with CuAAC click chemistry for attachment to azide‑bearing molecules.

References : Bejan D. S. et al.: Chem. Sci., 13(46), 13898-13906, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.