DDD107498

SI-3271

DDD107498, >98% (HPLC)

CAS No. : [1469439-69-7]

Synonyms : DDD 498

IUPAC Name : 6-Fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
100MG	195.00		Back Order	Estimated to ship on 04 October 2026
250MG	355.00		Back Order	Estimated to ship on 04 October 2026
1G	995.00		Back Order	Estimated to ship on 04 October 2026
Note: DDD107498is not in stock but can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and Mass analysis. Purity (HPLC) is usually >98%. COA, QC data and SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or Request A Quote. We respond promptly. Thank You!

Applications : DDD107498 is a multiple-stage antimalarial agent that inhibits protein synthesis. DDD107498 demonstrates potential to address a variety of clinical needs, including single-dose treatment, transmission blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis. This discovery of eEF2 as a viable antimalarial drug target opens up new possibilities for drug discovery.

References : Fidock D. A. et al.: Nature 522(7556), 315-320, 2015; Baragana B. et al.: J. Med. Chem., 59(21), 9672-9685, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.