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Decernotinib

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SI-5360

Decernotinib, >98% (HPLC)

CAS No. : [944842-54-0]

MDL No. : MFCD27987896

Synonyms : VRT-831509; VX-509

IUPAC Name : (R)-2-((2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide

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Chemical Properites
Mol. Formula :
C18H19F3N6O
Mol. Weight :
392.39
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Decernotinib is a potent, orally active JAK3 inhibitor, with Kis of 2.5, 11, 13 and 11 nM for JAK3, JAK1, JAK2, and TYK2, respectively. It is used for the treatment of autoimmune diseases.

References : Mahajan S. et al.: J. Pharmacol Exp Ther., 353(2), 405-414, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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