Dehydro-lovastatin

SL-3514

Dehydro-lovastatin, >98%

CAS No. : [109273-98-5]

Synonyms : Dehydromonacolin K; α, β-Dehydrolovastatin; Lovastatin EP impurity C; L 642257

IUPAC Name : (1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-(2-((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate

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Applications : Dehydro-lovastatin is an impurity of Lovastatin (Lovastatin EP impurity C), which is an inhibitor of HMG-CoA reductase, used for lowering cholesterol (hypolipidemic agent).

References : Pahan K. et al.: J. Clin. Invest., 100(11), 2671-2679, 1997; Keyomarsi K. et al.: Cancer Res., 51(13), 3602-3609, 1991; Tobert J. A. et al.: Nat Rev Drug Discov., 2(7), 517-526, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.