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Delgocitinib

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SI-6280

Delgocitinib, >98% (HPLC)

CAS No. : [1263774-59-9]

Synonyms : JTE-052

IUPAC Name : 3-((3S,4R)-3-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl)-3-oxopropanenitrile

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Chemical Properites
Mol. Formula :
C16H18N6O
Mol. Weight :
310.36
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Delgocitinib inhibits JAK1, JAK2, JAK3, and TYK2 with low‑nanomolar potency (IC50 = 2.8/2.6/13/58 nM), making it a valuable tool for dissecting JAK‑mediated cytokine signaling.

References : Tanimoto A. et al.: Inflamm. Res., 64(1), 41-51, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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