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Demethyl isradipine

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SL-4554

Demethyl isradipine, >98%

CAS No. : [88977-30-4]

IUPAC Name : 4-(Benzo[c][1,2,5]oxadiazol-4-yl)-5-(isopropoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid

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Chemical Properites
Mol. Formula :
C18H19N3O5
Mol. Weight :
357.37
Appearance :
Pale yellow solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of Isradipine and related analogs. Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure in order to reduce the risk of stroke and heart attack.

References : Nez-Vergara L. J. et al.: Gen Pharmacol, 30(1), 85-87, 1998; Barhwal K. et al.: Neurobiol Dis, 34(2), 230-244, 2009; Fadda F. et al.: Alcohol Clin Exp Res, 16(3), 449-452, 1992; Levy B. I. et al.: Circulation, 90(6), 3024-3033, 1994; Kuzmin A. et al.: Pharmacol Biochem Behav, 41(3), 497-500,1992.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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