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Depyrazine 7,8-dinitrophenyl varenicline

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Depyrazine 7,8-dinitrophenyl varenicline, >98%

CAS No. : [230615-08-4]

IUPAC Name : 7,8-Dinitro-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine

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Chemical Properites
Mol. Formula :
C11H11N3O4
Mol. Weight :
249.23
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This compound is an advanced key intermediate used in the synthesis of Varenicline, which is a potent partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR), and currently being explored as a potential treatment for smoking cessation.

References : Mihalak K. B. et al.: Mol Pharmacol., 70(3), 801-805, 2006; Bagdas D. et al.: Neuropharmacology 138, 72-79, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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