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Des(methylpiperazinyl-N-methyl)imatinib dimer

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SL-3392

Des(methylpiperazinyl-N-methyl)imatinib dimer, >98%

CAS No. : [1365802-18-1]

IUPAC Name : 1,4-Bis-[4-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]carbamoyl]benzylpiperazine

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Chemical Properites
Mol. Formula :
C52H48N12O2
Mol. Weight :
873.02
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Des(methylpiperazinyl-N-methyl)imatinib dimer is an impurity of Imatinib, which is a tyrosine kinases inhibitor for the treatment of cancer.

References : Heinrich M. C. et al.: Blood. 96(3), 925-932, 2000; Guida T. et al.: Clin Cancer Res. 13(11), 3363-3369, 2007; Okuda K. et al.: Blood. 97(8), 2440-2448, 2001; Yao J. C. et al.: Clin Cancer Res. 13(1), 234-240, 2007; Sun X. C. et al.: World J. Gastroenterol. 19(15), 2340-2347, 2013; Yildiz C. et al.: Eur J. Obstet Gynecol Reprod Biol. 197, 159-163, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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