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Desisopropylthiazolyl ritonavir

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Desisopropylthiazolyl ritonavir, >98%

CAS No. : [176655-57-5]

Synonyms : Ritonavir impurity 18

IUPAC Name : Thiazol-5-ylmethyl ((2S,3S,5S)-3-hydroxy-5-((S)-3-methyl-2-(3-methylureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate

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Chemical Properites
Mol. Formula :
C30H39N5O5S
Mol. Weight :
581.73
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Ritonavir, which is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor.

References : Eagling V. A. et al.: Br. J. Clin Pharmacol.,44(2), 190-194, 1997; Kumar G. N. et al.: J. Pharmacol Exp Ther., 277(1), 423-431, 1996; Weichold F. F. et al.: J. Hum Virol., 2(5), 261-269, 1999; Drewe J. et al.: Biochem Pharmacol., 57(10), 1147-52, 1999; Kumar G. N. et al.: Drug Metab Dispos. 27(8), 902-8, 1999; Qi S. et al.: Signal Transduct Target Ther., 6(1), 212, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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