Desmorpholinyl quizartinib-PEG2-COOH

SI-6939

Desmorpholinyl quizartinib-PEG2-COOH, >98% (HPLC)

CAS No. : [2292116-14-2]

IUPAC Name : 3-(2-(2-((2-(4-(3-(5-(tert-Butyl)isoxazol-3-yl)ureido)phenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethoxy)ethoxy)propanoic acid

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Applications : Desmorpholinyl Quizartinib‑PEG2‑COOH couples a Quizartinib‑derived FLT3‑binding moiety with a PEG2 PROTAC linker, serving as a key precursor for constructing PROTAC FLT‑3 degrader 1. The resulting degrader potently eliminates FLT3‑ITD, exhibiting an IC₅₀ of 0.6 nM.

References : Burslem G. M. et al.: J. Am. Chem. Soc., 140(48), 16428-16432, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.