Dexrazoxane dihydrochloride

SL-10423

Dexrazoxane dihydrochloride, >98%

CAS No. : [149003-01-0]

Synonyms : ICRF-187 dihydrochloride; ADR-529 dihydrochloride; NSC-169780 dihydrochloride

IUPAC Name : (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione) dihydrochloride

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Applications : Dexrazoxane dihydrochloride is an intracellular iron chelator, decreases superoxide radical formation and offers cardioprotective, anti-inflammatory, antioxidant, anti-tumor, and neuroprotective benefits. It prevents ferroptosis in H9c2 cells by inhibiting HMGB1 and induces DNA damage and apoptosis in human fibrosarcoma cells.

References : Rahimi P. et al.: Cureus 15(4), e37308, 2023; Lebrecht D. et al.: Br J. Pharmacol. 151(6), 771-8, 2007; de Baat E. C. et al.: Lancet Child Adolesc Health 6(12), 885-894, 2022; Deng S. et al.: Br. J. Pharmacol., 172(9), 2246-57, 2015; Zhang H. et al.: Front Cardiovasc Med., 8, 685434, 2021; Mei M. et al.: Neuropharmacology, 160, 107758, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.