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DG-051 free acid

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SI-6413

DG-051 free acid, >98% (HPLC)

CAS No. : [929916-05-2]

IUPAC Name : (S)-4-(2-((4-(4-Chlorophenoxy)phenoxy)methyl)pyrrolidin-1-yl)butanoic acid

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Chemical Properites
Mol. Formula :
C21H24ClNO4
Mol. Weight :
389.88
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : DG-051 free acid binds LTA4H with a Kd of 26 nM and demonstrates excellent solubility and oral exposure (>30 mg/mL; >80% bioavailability). Its pharmacological profile supports its use in investigating leukotriene‑driven inflammation in models of myocardial infarction and stroke.

References : Sandanayaka V. et al.: J. Med. Chem., 53(2), 573-85, 2010; Enache L. A. et al.: Bioorg. Med. Chem. Lett., 19(22), 6275-9, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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