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DHODH-IN-22

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SI-7141

DHODH-IN-22, >98% (HPLC)

CAS No. : [2450341-75-8]

IUPAC Name : (S)-N-(3-Chloro-2-methoxy-5-methylpyridin-4-yl)-6-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)nicotinamide

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Chemical Properites
Mol. Formula :
C21H21ClF4N6O5
Mol. Weight :
548.88
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This potently inhibits DHODH with an IC50 of 0.3 nM and shows strong selectivity and oral activity. It is well suited for mechanistic and translational studies in AML.

References : Cisar J. S. et al.: J .Med. Chem., 65(16), 11241-11256, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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