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Dicyclomine-d4 hydrochloride

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Dicyclomine-d4 hydrochloride, >98%

Related CAS No. : [67-92-5] of the unlabelled compound

Synonyms : Dicycloverine-d4 hydrochloride

IUPAC Name : 2-(Diethylamino)ethyl-1,1,2,2-d4 [1,1'-bi(cyclohexane)]-1-carboxylate hydrochloride

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Chemical Properites
Mol. Formula :
C19H31D4NO2 • HCl
Mol. Weight :
349.98
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Dicyclomine hydrochloride, which is a potent and orally active muscarinic cholinergic receptors antagonist. It shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.

References : Pavía J. et al.: Eur. J. Pharmacol., 320(2-3), 209-14, 1997; Antonella C. et al.: Neuron 49(5), 671-82, 2006; Susan J. B. et al.: Psychopharmacology (Berl) 214(2), 537-48, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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