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Dihydro dutasteride

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SL-10482

Dihydro dutasteride, >98%

CAS No. : [164656-22-8]

IUPAC Name : (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-Bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide

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Chemical Properites
Mol. Formula :
C27H32F6N2O2
Mol. Weight :
530.56
Appearance :
Solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Dutasteride, which is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.

References : Lazier C. B. et al.: Prostate, 58(2), 130-44, 2004; Biancolella M. et al.: Invest New Drugs, 25(5), 491-7, 2007; Bramson H. N. et al.: J. Pharmacol Exp Ther. 282(3), 1496-502, 1997; Andriole G. L. et al.: J. Urol., 175(5), 1657-62, 2006;
Margiotta-Casaluci L. et al.: Aquat Toxicol., 128-129, 113-23, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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