Dinaciclib

SI-6258

Dinaciclib, >98% (HPLC)

CAS No. : [779353-01-4]

Synonyms : SCH-727965

IUPAC Name : (S)-3-(((3-Ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)pyridine 1-oxide

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Applications : Dinaciclib inhibits several key cyclin‑dependent kinases with sub‑nanomolar to low‑nanomolar potency (CDK2 = 1 nM, CDK5 = 1 nM, CDK1 = 3 nM, CDK9 = 4 nM). This multi‑target profile makes it a valuable tool for probing CDK‑dependent mechanisms in tumor cell proliferation and survival.

References : Parry D. et al.: Mol. Cancer Ther., 9(8), 2344-53, 2010; Feldmann G. et al.: Cancer Biol. Ther., 12(7), 598-609, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.