Diroximel fumarate impurity B

SL-9406

Diroximel fumarate impurity B, >98%

CAS No. : [2101811-40-7]

IUPAC Name : Bis(2-(2,5-dioxopyrrolidin-1-yl)ethyl) fumarate

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Applications : This is an impurity of Diroximel fumarate, which is an orally active, well-tolerated monomethyl fumarate (MMF) proagent in controlled-release form. Diroximel fumarate is considered pharmacologically equivalent to its active metabolite, Dimethyl fumarate (DMF). With a favourable safety and efficacy profile, Diroximel fumarate shows potential for multiple sclerosis (MS) research. As a Nrf2 activator, it alleviates MGO-induced pain hypersensitivity.

References : Angela W. et al.: Neurology (P1.403), Apr 2018; Yousuf M. S. bioRxiv 12, 22, 572877, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.