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Domatinostat

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SL-1639

Domatinostat, >98%

CAS No. : [910462-43-0]

MDL No. : MFCD28155264

Synonyms : 4SC-202

IUPAC Name : (E)-N-(2-Aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide

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Chemical Properites
Mol. Formula :
C23H21N5O3S
Mol. Weight :
447.51
Appearance :
Light yellow solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Domatinostat is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).

References : Pinkerneil M. et al.: Target Oncol., (6), 783-798, 2016; Zhijun H. et al.: Tumour Biol., 37(8), 10257-10267,2016; Fu M. et al.: Biochem Biophys Res Commun., 471(2), 267-273, 2016

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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