Doramapimod

SI-6365

Doramapimod, >98% (HPLC)

CAS No. : [285983-48-4]

Synonyms : BIRB-796

IUPAC Name : 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Doramapimod potently inhibits p38α, p38β, p38γ, and p38δ with low‑ to mid‑nanomolar IC₅₀ values and binds p38 kinase with picomolar affinity. It also targets B‑Raf at nanomolar potency. This pharmacological profile makes Doramapimod a valuable tool for dissecting p38‑dependent inflammatory and proliferative signaling pathways.

References : Dietrich J. et al.: Bioorg. Med. Chem., 18(15), 5738-48, 2010; Cicenas J. et al.: Cancers (Basel), 10(1), 2017; Kuma Y. et al.: J. Biol. Chem., 280(20), 19472-19479, 2005; He D. et al.: PLoS One, 8(1), e54181, 2013; Park J. K. et al.: Hypertension, 49(3), 481-9, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.