Doramapimod hydrochloride

SI-6366

Doramapimod hydrochloride, >98% (HPLC)

CAS No. : [1283526-53-3]

Synonyms : BIRB-796 hydrochloride

IUPAC Name : 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea hydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Doramapimod hydrochloride inhibits p38 MAPK–mediated inflammatory signaling and strongly suppresses TNF‑α and IL‑1β responses to LPS, LTA, and PGN. Its enhanced activity across multiple bacterial toxin models highlights its value for investigating autoimmune and other inflammation‑related pathologies.

References : Dietrich J. et al.: Bioorg. Med. Chem., 18(15), 5738-48, 2010; Cicenas J. et al.: Cancers (Basel), 10(1), 2017; Kuma Y. et al.: J. Biol. Chem., 280(20), 19472-19479, 2005; He D. et al.: PLoS One, 8(1), e54181, 2013; Park J. K. et al.: Hypertension, 49(3), 481-9, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.