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Dorzolamide intermediate enantiomer

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Dorzolamide intermediate enantiomer, >98%

Synonyms : Enantiomer of dorzolamide N-desethyl N-acetyl analog

IUPAC Name : N-((4R,6R)-6-Methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)acetamide

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Chemical Properites
Mol. Formula :
C10H14N2O5S3
Mol. Weight :
338.41
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an enantiomer intermediate of Dorzolamide, which is a potent carbonic anhydrase II inhibitor. Dorzolamide is used to lower excessive intraocular pressure in open-angle glaucoma and ocular hypertension.

References : Biollaz J. et al.: Eur. J. Clin Pharmacol., 47(5), 455-60, 1995; Sangly P. et al.: Invest Ophthalmol Vis Sci., 43(10), 3273-8, 2002; Ali M. B. et al.: Naunyn Schmiedebergs Arch Pharmacol., 388(12), 1271-82, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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