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Dovitinib lactate

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SI-6040

Dovitinib lactate, >98% (HPLC)

CAS No. : [692737-80-7]

MDL No. : MFCD23103506

Synonyms : CHIR-258 lactate; TKI-258 lactate

IUPAC Name : 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate

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Chemical Properites
Mol. Formula :
C21H21FN6O . C3H6O3
Mol. Weight :
482.52
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Dovitinib lactate is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor for the potential treatment of renal cell carcinoma (RCC).

References : Trudel S. et al.: Blood, 105(7), 2941-2948, 2005; Huynh H. et al.: J. Hepatol., 56(3), 595-601, 2012; Lee Y. et al.: Mol Cells 39(5), 389-94, 2016; Chon H. J. et al.: Amino Acids 48(7),1591-9, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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